Quantifying the global contribution of alcohol consumption to cardiomyopathy

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The global impact of alcohol consumption on deaths due to cardiomyopathy (CM) has not been quantified to date, even though CM contains a subcategory for alcoholic CM with an effect of heavy drinking over time ...

2017-05-25 01:00:00  

Multiple cause-of-death data among people with AIDS in Italy: a nationwide cross-sectional study

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Multiple cause-of-death (MCOD) data allow analyzing the contribution to mortality of conditions reported on the death certificate that are not selected as the underlying cause of death. Using MCOD data, this s...

2017-05-18 01:00:00  

Evolution of the “fourth stage” of epidemiologic transition in people aged 80 years and over: population-based cohort study usi

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In the “fourth stage” of epidemiological transition, the distribution of non-communicable diseases is expected to shift to more advanced ages, but age-specific changes beyond 80 years of age have not been repo...

2017-05-12 01:00:00  

Adult mortality of diseases and injuries attributable to selected metabolic, lifestyle, environmental, and infectious risk fact

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To facilitate priority-setting in health policymaking, we compiled the best available information to estimate the adult mortality (>30 years) burden attributable to 13 metabolic, lifestyle, infectious, and env...

2017-05-03 01:00:00  

Self-reported general health, physical distress, mental distress, and activity limitation by US county, 1995-2012

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Metrics based on self-reports of health status have been proposed for tracking population health and making comparisons among different populations. While these metrics have been used in the US to explore disp...

2017-04-26 01:00:00  

Feasibility of focal cerebral ischemia and reperfusion surgery combined with chronic unpredictable mild stress to simulate the

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To evaluate the feasibility of focal cerebral ischemia and reperfusion (FCIR) surgery combined chronic unpredictable mild stress (CUMS) to simulate the post-stroke depression (PSD) state in rats.

2015-12-24 00:00:00  

Multivariable analysis to determine if HIV-1 Tat dicysteine motif is associated with neurodevelopmental delay in HIV-infected c

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HIV-1 Tat protein is implicated in HIV-neuropathogenesis. Tat C31S polymorphism (TatCS) has been associated with milder neuropathology in vitro and in animal models but this has not been addressed in a cohort of ...

2015-12-17 00:00:00  

Decreased functional connectivity between ventral tegmental area and nucleus accumbens in Internet gaming disorder: evidence fr

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Internet gaming disorder (IGD) has become an increasing mental health problem worldwide. Decreased resting-state functional connectivity (rsFC) between the ventral tegmental area (VTA) and the nucleus accumben...

2015-11-18 00:00:00  

Physical fatigue increases neural activation during eyes-closed state: a magnetoencephalography study

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Fatigue, defined as difficulty initiating or sustaining voluntary activities, can be classified as physical or mental. In this study, we use magnetoencephalography (MEG) to quantify the effect of physical fati...

2015-11-05 00:00:00  

Serum concentrations of kynurenines in adult patients with attention-deficit hyperactivity disorder (ADHD): a case–control stud

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The essential amino acid tryptophan is catabolised mainly through the kynurenine pathway. Altered circulating levels of kynurenines have been reported in chronic inflammatory conditions and in several neuropsy...

2015-11-05 00:00:00  

Projected growth of the adult congenital heart disease population in the United States to 2050: an integrative systems modelin

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Background: Mortality for children with congenital heart disease (CHD) has declined with improved surgical techniques and neonatal screening; however, as these patients live longer, accurate estimates of the prevalence of adults with CHD are lack

2015-10-15 00:00:00  

Measuring causes of death in populations: a new metric that corrects cause-specific mortality fractions for chance

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Background: Verbal autopsy is gaining increasing acceptance as a method for determining the underlying cause of death when the cause of death given on death certificates is unavailable or unreliable, and there are now a number of alternative appr

2015-10-12 12:00:00  

Validation of a new predictive risk model: measuring the impact of the major modifiable risks of death for patients and popula

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Background: Modifiable risks account for a large fraction of disease and death, but clinicians and patients lack tools to identify high risk populations or compare the possible benefit of different interventions. Methods: We used data on the dist

2015-10-01 12:00:00  

The importance of regional availability of health care for old age survival - Findings from German reunification

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Background: This article investigates the importance of regional health care availability for old age survival. Using German reunification as a natural experiment, we show that spatial variation in health care in East Germany considerably influen

2015-09-29 12:00:00  

Estimating the current mean age of mothers at the birth of their first child from household surveys

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Background: Estimates of the period mean age at first birth are readily available for countries with accurate vital statistics (i.e., in much of the developed world). In contrast, in most developing countries vital statistics are lacking or incom

2015-09-14 12:00:00  

The Population Health Model (POHEM): an overview of rationale, methods and applications

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The POpulation HEalth Model (POHEM) is a health microsimulation model that was developed at Statistics Canada in the early 1990s. POHEM draws together rich multivariate data from a wide range of sources to simulate the lifecycle of the Canadian p

2015-09-03 12:00:00  

A method for reclassifying cause of death in cases categorized as “event of undetermined intent”

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Background: We present a method for reclassifying external causes of death categorized as “event of undetermined intent” (EUIs) into non-transport accidents, suicides, or homicides. In nations like Russia and the UK the absolute number of EUIs is

2015-09-02 12:00:00  

Mapping HIV prevalence using population and antenatal sentinel-based HIV surveys: a multi-stage approach

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Background: Sound public health policy on HIV/AIDS depends on accurate prevalence and incidence statistics for the epidemic at both local and national levels. However, HIV statistics derived from epidemiological extrapolation models and data sour

2015-09-02 12:00:00  

Multiple causes of death analysis of chronic diseases: the example of diabetes

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Background: Identifying a single disease as the underlying cause of death (UCOD) is an oversimplification of the clinical-pathological process leading to death. The multiple causes of death (MCOD) approach examines any mention of a disease in dea

2015-08-25 12:00:00  

High rates of homicide in a rural South African population (2000–2008): findings from a population-based cohort study

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Background: South Africa has continued to receive increasing attention due to unprecedented high levels of violence. Homicide-related violence accounts for a significant proportion of unnatural deaths and contributes significantly to loss of year

2015-08-07 12:00:00  

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